LeuT-Desipramine Structure Reveals How Antidepressants Block Neurotransmitter Reuptake
نویسندگان
چکیده
منابع مشابه
Biochemistry Select
Transporter proteins bind ions and small molecules and transfer them across lipid membranes. Recent studies on transporters, discussed in this issue's Biochemistry Select, provide insight into the family of proteins targeted by tricyclic antidepressants. Other work sheds light on glucose absorption in the gut, host-pathogen interactions , and a mechanism used by an important food crop to adapt ...
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Neurotransmitter/sodium symporters (NSSs) are responsible for Na+-dependent reuptake of neurotransmitters and represent key targets for antidepressants and psychostimulants. LeuT, a prokaryotic NSS protein, constitutes a primary structural model for these transporters. Here we show that K+ inhibits Na+-dependent binding of substrate to LeuT, promotes an outward-closed/inward-facing conformation...
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ژورنال
عنوان ژورنال: Science
سال: 2007
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.1147614